The aim of the study was to investigate the protective effects of Launaea procumbens methanolic\r\nextract (LM) against CCl4-induced molecular, hormonal and pathological abnormalities in rats. Male\r\nSprague Dawley rats were provided by National Institute of Health (NIH) Islamabad and orally fed with\r\n100, 200 mg/kg body weight of LM after 48 h of CCl4 treatment (3 ml/kg body weight, 30% in olive oil)\r\nbiweekly for 4 weeks. The results showed that the administration of LM significantly improved the CCl4-\r\ninduced serum level of hormones, argyrophilic nucleolar organizer regions (AgNORs) and DNA\r\ndamages. Histopathology showed that LM reduced the incidence of adrenal lesions induced by CCl4 in\r\nrats. These results suggest that LM could protect adrenal against the CCl4-induced oxidative damage in\r\nrats.
Loading....